Genomics of Inflammation and Immunity


We use high-throughput genetic and genomic screens, plus immunological assays, to identify drug targets for immune-mediated disease, with a particular focus on primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD).

What we are doing

Genetics

We perform large scale screening of human genomes to identify genetic variants influencing immune-mediated diseases (e.g. IBD and PSC) and immune responses in health (e.g. following vaccination).

Genomics

We use sequencing (e.g RNA-seq and ATAC-seq) to identify regulatory elements in disease relevant cells, and then map the genetic variants that influence these.

Immunology

In our wet lab we perform high-throughput screens (e.g. CRISPR screens) and cellular assays to understand the biological mechanisms via which disease-associated variants mitigate risk.