Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin

Olafsson, S., Rodriguez, E., Lawson, A.R.J. et al.
Nature Genetics 2023 Oct

Baseline expression of immune gene modules in blood is associated with primary response to anti-TNF therapy in Crohn’s disease patients

Bai, B., Reppell, M., Smaoui, N., Waring, J., et al.
Journal of Crohn's and Colitis 2023 Sep

Single-cell RNA sequencing reveals dysregulated cellular programmes in the inflamed epithelium of Crohn’s disease patients

Krzak, M., Alegbe, T., Taylor D. L., N., Ghouraba, M., et al.
medrxiv 2023 Sep

Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn’s disease

Lin, S., Hannon, E., Reppell, M., Waring, J. F., et al.
Journal of Crohn's and Colitis 2023 Aug

Low-usage splice junctions underpin immune mediated disease risk

El Garwany, O., Panousis, N. I., Knights, A., Kumasaka, N., et al.
biorxiv 2023 May

Gene expression QTL mapping in stimulated iPSC derived macrophages provides insights into common complex diseases

Panousis, N. I,. El Garwany, O., Knights, A., Rop, J. C., et al.
biorxiv 2023 May

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Barrio-Hernandez, I., Schwartzentruber, J., Shrivastava, A., Del-Toro, N., et al.
Nature Genetics 2023 March

Genomic diagnosis and care co-ordination for monogenic inflammatory bowel disease in children and adults: consensus guideline on behalf of the British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition

Kammermeier, J., Lamb, C. A., Jones, K. D. J., Anderson, C. A., et al.
The lancet. Gastroenterology & hepatology 2023 Jan

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Sazonovs, A., Stevens, C.R., Venkataraman, G.R. et al.
Nat Genet. 2022 Aug

Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin

Olafsson S, Rodriguez E, Lawson AR, et al.
MedRxiv. 2022 July

Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases

Kundu K, Tardaguila M, Mann AL, Watt S, Ponstingl H, Vasquez L, Von Schiller D, Morrell NW, Stegle O, Pastinen T, Sawcer SJ, Anderson CA, Walter K, Soranzo N.
Nat Genet. 2022 Mar

An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease

Bolton C, Smillie CS, Pandey S, et al.
Gastroenterology. 2022 Mar

ShaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores

M. Kelemen, E. Vigorito, C. A. Anderson, C. Wallace
MedRxiv. 2021 Dec

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Eijsbouts C, Zheng T, Kennedy NA, et al.
Nature Genetics. 2021 Nov

Somatic mutations provide important and unique insights into the biology of complex diseases

Olafsson S, Anderson CA
Trends in Genetics. 2021 July

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Barrio-Hernandez, SchwartzentruberShrivastava A, et al.
Biorxiv. 2021 July

Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohn's disease susceptibility

Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, et al.
MedRxiv. 2021 June

Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort

Gettler K, Levantovsky R, Moscati A, et al.
Gastroenteroloy, 2021 April

Underpowered PANTS: a response to the conclusions of "Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab"

Sazonovs A, Ahmad T, Anderson CA.
Gastroenterology. 2020 Oct 3;S0016-5085(20)35225-2.

Somatic Evolution in Non-neoplastic IBD-Affected Colon

Olafsson S, McIntyre RE, Coorens T, Butler T, Jung H, et al.,
Cell. 2020 Aug 6;182(3):672-684.e11.

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Serra EG, Schwerd T, Moutsianas L, Cavounidis A, Fachal L, et al.,
Nat Commun. 2020 Feb 21;11(1):995.

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.

Petrova VN, Sawatsky B, Han AX, Laksono BM, et al.,
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HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Sazonovs A, Kennedy NA, Moutsianas L, Heap GA, et al.
Gastroenterology 2019

Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System.

Goode EC, Clark AB, Mells GF, Srivastava B, Spiess K, et al.
Hepatology. 2019 69(5)2120-2135

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

Walker GJ, Harrison JW, Heap GA, Voskuil MD, et al.
JAMA. 2019 321(8):773-785

Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.

Cangul H, Liao XH, Schoenmakers E, Kero J, et al.,
JCI Insight. 2018 Oct 18;3(20).

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia.

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Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

Quaranta M, Wilson R, Gonçalves Serra E, Pandey S, et al.,
Gastroenterology. 2018 Jul;155(1):231-234.

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

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PLoS Genet. 2018 May 24;14(5):e1007329.

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.

Schwerd T, Bryant RV, Pandey S, Capitani M, et al.,
Mucosal Immunol. 2018 Mar;11(2):562-574.

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

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Gut. 2018 Aug;67(8):1517-1524.

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G et al.
Nature 2017;547;7662;173-178

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J et al.
Nature genetics 2017;49;2;186-192

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

de Lange KM, Moutsianas L, Lee JC, Lamb CA, Luo Y et al.
Nature genetics 2017;49;2;256-261

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L et al.
Nature genetics 2017;49;2;269-273

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC et al.
Nature genetics 2017;49;2:262-268

A reference panel of 64,976 haplotypes for genotype imputation.

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR et al.
Nature genetics 2016;48;10;1279-83

Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ.

Nicholas AK, Serra EG, Cangul H, Alyaarubi S, Ullah I et al.
The Journal of clinical endocrinology and metabolism 2016;jc20161879

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN et al.
Nature communications 2016;7;12342

Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci.

Saadati HR, Wittig M, Helbig I, Häsler R, Anderson CA et al.
BMC medical genetics 2016;17;26

Class II HLA interactions modulate genetic risk for multiple sclerosis.

Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK et al.
Nature genetics 2015;47;10;1107-13

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R et al.
Nature genetics 2015;47;9;979-986

Genetics in PSC: what do the "risk genes" teach us?

Folseraas T, Liaskou E, Anderson CA and Karlsen TH
Clinical reviews in allergy & immunology 2015;48;2-3;154-64

Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

Raine T, Liu JZ, Anderson CA, Parkes M and Kaser A
Gut 2015;64;2;250-9

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L et al.
Nature genetics 2015;47;2;172-9

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM et al.
Nature communications 2015;6;8019

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L et al.
American journal of human genetics 2014;94;6;915-23

Genetic studies of Crohn's disease: past, present and future.

Liu JZ and Anderson CA
Best practice & research. Clinical gastroenterology 2014;28;3;373-86

Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

Williamson KA, Rainger J, Floyd JA, Ansari M, Meynert A et al.
American journal of human genetics 2014;94;2;295-302

Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.

Houldcroft CJ, Petrova V, Liu JZ, Frampton D, Anderson CA et al.
PloS one 2014;9;10;e108384

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF et al.
Nature genetics 2013;45;11;1353-60

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM et al.
Cell 2013;155;1;57-69

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM et al.
Nature genetics 2013;45;6;670-5

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.

Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA et al.
PLoS genetics 2013;9;9;e1003723

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP et al.
Nature 2012;491;7422;119-24

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L et al.
Nature genetics 2012;44;10;1137-41

optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants.

Shah TS, Liu JZ, Floyd JA, Morris JA, Wirth N et al.
Bioinformatics (Oxford, England) 2012;28;12;1598-603

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS et al.
Nature genetics 2011;43;4;329-32

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M et al.
Nature genetics 2011;43;3;246-52

Synthetic associations are unlikely to account for many common disease genome-wide association signals.

Anderson CA, Soranzo N, Zeggini E and Barrett JC
PLoS biology 2011;9;1;e1000580

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J et al.
Nature genetics 2011;43;1;51-4

Data quality control in genetic case-control association studies.

Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP and Zondervan KT
Nature protocols 2010;5;9;1564-73

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M et al.
Gastroenterology 2009;136;2;523-9.e3

Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

Anderson CA, Pettersson FH, Barrett JC, Zhuang JJ, Ragoussis J et al.
American journal of human genetics 2008;83;1;112-9

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L et al.
American journal of human genetics 2014;94;6;915-23

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L et al.
American journal of human genetics 2014;94;6;915-23

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L et al.
American journal of human genetics 2014;94;6;915-23